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KMID : 0358920010280030430
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Journal of the Korean Academy of Pedodontics
2001 Volume.28 No. 3 p.430 ~ p.440
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THE COMPARATIVE STUDY ON THE EFFICACY OF CHLORAL HYDRATE AND HYDROXYZINE OF DIFFERENT DOSES IN SEDATING YOUNG PEDIATRIC DENTAL PATIENTS
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Lee In-Cheoun
Kim Jong-Soo
Kim Soon-Won
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Abstract
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Orally administered chloral hydrate is often used, because of it’s wide margin of safety and relatively few sideeffects. Hydroxyzine is an antihistamine with sedative and anti-emetic properties. It has been used in conjunction with chloral hydrate to reduce the incidence of nausea and vomiting. But, it’s therapeutic drug concentration has not been established. The purpose of this study was to assess the sedative effect and physiologic parameter of hydroxyzine of different doses in sedating young pediatric dental patients. Fifty uncooperative children, mean age 33.2 months, who needed at least four separate restorative visits, requiring local anesthesia participated in this study. On every visit, one of the following 4 different sedative regimen was given (1) 70mg/kg CH (2) 70mg/kg CH and 1mg/kg HD (3) 70mg/kg CH and 2mg/kg HD (4) 70mg/kg CH and 3mg/kg HD. Physiologic parameter was recorded and behavior was videotaped and rated using Ohio State University Behavior Rating Scale by one investigator, blind to the dose. The analyzed sedative effect of combined oral administration of 70mg/kg chloral hydrate and 2mg/kg hydroxyzine was superior to the other regimens. Evidence of adverse effect was not detected or reported during and/or after the procedures.
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KEYWORD
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Hydroxyzine, Chloral hydrate, Sedative effect
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